Johannes Loffing Selected Research

Sodium Chloride Symporters

12/2015	ENaC activity in collecting ducts modulates NCC in cirrhotic mice.
9/2014	Gitelman syndrome and glomerular proteinuria: a link between loss of sodium-chloride cotransporter and podocyte dysfunction?
3/2014	Hydrochlorothiazide attenuates lithium-induced nephrogenic diabetes insipidus independently of the sodium-chloride cotransporter.
8/2008	Upregulation of apical sodium-chloride cotransporter and basolateral chloride channels is responsible for the maintenance of salt-sensitive hypertension.

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Johannes Loffing Research Topics

Disease

15	Hypertension (High Blood Pressure) 10/2021 - 09/2003
10	Hyperkalemia 10/2021 - 02/2013
6	Gitelman Syndrome 01/2020 - 09/2004
5	Pseudohypoaldosteronism 01/2018 - 01/2016
4	Acidosis 10/2021 - 01/2016
4	Body Weight (Weight, Body) 01/2021 - 06/2007
3	Alkalosis 01/2022 - 09/2004
3	Hypercalciuria 10/2021 - 02/2013
3	Hypokalemia 01/2021 - 01/2017
3	Nephrogenic Diabetes Insipidus 07/2016 - 02/2011
3	Hypovolemia 01/2016 - 10/2010
2	Weight Loss (Weight Reduction) 01/2022 - 10/2017
2	Hyponatremia 10/2021 - 07/2016
2	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2020 - 12/2005
2	Bartter Syndrome (Syndrome, Bartter) 12/2019 - 06/2008
2	Dehydration (Water Stress) 10/2017 - 01/2016
2	Inflammation (Inflammations) 01/2017 - 06/2005
2	Polyuria 01/2017 - 02/2011
2	Ascites 12/2015 - 12/2005
2	Proteinuria 09/2014 - 10/2012
2	Kidney Diseases (Kidney Disease) 08/2014 - 01/2012
2	Hypotension (Low Blood Pressure) 03/2014 - 01/2014
2	Liddle Syndrome 02/2013 - 09/2003
2	Hyperaldosteronism (Conn Syndrome) 11/2012 - 08/2006
1	Hypoxia (Hypoxemia) 10/2021
1	Asthma (Bronchial Asthma) 01/2021
1	SeSAME syndrome 01/2020
1	Atrophy 01/2020
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2019
1	Meniere Disease (Menieres Disease) 01/2019
1	Cysts 01/2019
1	Kidney Calculi (Kidney Stone) 10/2018
1	Wasting Syndrome (Wasting Disease) 01/2018
1	Bipolar Disorder (Manic Depressive Psychosis) 07/2016
1	Hypercalcemia (Milk Alkali Syndrome) 07/2016
1	Failure to Thrive 01/2016
1	Fibrosis (Cirrhosis) 12/2015
1	Ischemia 11/2015
1	Stroke (Strokes) 03/2015
1	Disease Susceptibility (Diathesis) 12/2013
1	Genetic Predisposition to Disease (Genetic Predisposition) 12/2013
1	Pre-Eclampsia (Preeclampsia) 10/2012

Drug/Important Bio-Agent (IBA)

17	SaltsIBA 01/2020 - 09/2003
16	SodiumIBA 10/2021 - 09/2005
12	AldosteroneIBA 01/2021 - 09/2004
8	ThiazidesIBA 01/2020 - 09/2004
7	Proteins (Proteins, Gene)FDA Link 01/2019 - 02/2002
6	Epithelial Sodium ChannelsIBA 10/2021 - 09/2003
6	PotassiumIBA 01/2020 - 01/2014
6	Amiloride (Midamor)FDA LinkGeneric 01/2017 - 04/2002
5	Member 3 Solute Carrier Family 12IBA 01/2018 - 06/2005
4	Adenosine Triphosphatases (ATPase)IBA 10/2021 - 12/2005
4	Sodium Chloride FDA LinkGeneric 01/2020 - 07/2014
4	UromodulinIBA 12/2019 - 12/2013
4	Sodium Chloride SymportersIBA 12/2015 - 08/2008
3	SymportersIBA 01/2020 - 09/2004
3	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 01/2017 - 01/2016
3	LithiumIBA 07/2016 - 02/2011
3	ElectrolytesIBA 01/2016 - 11/2012
3	Phosphotransferases (Kinase)IBA 07/2014 - 01/2014
3	Hydrochlorothiazide (Esidrix)FDA LinkGeneric 03/2014 - 06/2005
2	Pharmaceutical PreparationsIBA 01/2021 - 07/2014
2	Transient Receptor Potential ChannelsIBA 01/2020 - 06/2005
2	Dietary PotassiumIBA 03/2015 - 01/2014
2	Aquaporin 2IBA 02/2011 - 04/2002
1	Urea (Carbamide)FDA LinkGeneric 01/2022
1	NitrogenIBA 01/2022
1	Hemoglobins (Hemoglobin)IBA 01/2022
1	Oxygen (Dioxygen)IBA 10/2021
1	oxalylglycineIBA 10/2021
1	Adenosine Triphosphate (ATP)IBA 10/2021
1	Chloride-Bicarbonate AntiportersIBA 10/2021
1	CalcineurinIBA 10/2021
1	ProteomeIBA 10/2021
1	Tacrolimus (Prograf)FDA LinkGeneric 10/2021
1	Calcineurin InhibitorsIBA 10/2021
1	Albuterol (Salbutamol)FDA LinkGeneric 01/2021
1	ReninIBA 01/2020
1	Messenger RNA (mRNA)IBA 01/2019
1	Hormones (Hormone)IBA 01/2019
1	Nuclear Pore Complex Proteins (Nucleoporins)IBA 01/2019
1	MorpholinosIBA 01/2019
1	CalciumIBA 10/2018
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2018
1	Purinergic P2X4 ReceptorsIBA 10/2018
1	Furosemide (Lasix)FDA LinkGeneric 10/2018
1	macitentanIBA 01/2017
1	Vitamin D FDA LinkGeneric 01/2017
1	Endothelin-1 (Endothelin 1)IBA 01/2017
1	MineralocorticoidsIBA 01/2017
1	Acetazolamide (Diamox)FDA LinkGeneric 07/2016
1	Antihypertensive Agents (Antihypertensives)IBA 03/2015
1	CreatinineIBA 02/2015
1	Type 1 Angiotensin ReceptorIBA 02/2015
1	Biomarkers (Surrogate Marker)IBA 08/2014
1	Protein Phosphatase 1IBA 03/2014
1	Angiotensin IIIBA 01/2014
1	Biological ProductsIBA 12/2013
1	Member 1 Solute Carrier Family 12IBA 12/2013

Therapy/Procedure

2	Ligation 12/2015 - 09/2005